{"id":2091,"date":"2020-03-23T20:53:17","date_gmt":"2020-03-23T20:53:17","guid":{"rendered":"http:\/\/noanimaltesting.ir\/?p=2091"},"modified":"2020-03-23T21:37:35","modified_gmt":"2020-03-23T21:37:35","slug":"%d9%85%db%8c%da%a9%d8%b1%d9%88%d8%af%d9%88%d8%b2%db%8c%d9%86%da%af-%d8%a7%d9%86%d8%b3%d8%a7%d9%86%db%8c%d8%8c-%d8%b1%d9%88%d8%b4%db%8c-%d8%a8%d8%b1%d8%a7%db%8c-%d9%be%db%8c%d8%b4-%da%af%d9%88%db%8c","status":"publish","type":"post","link":"https:\/\/noanimaltesting.ir\/?p=2091","title":{"rendered":"\u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af \u0627\u0646\u0633\u0627\u0646\u06cc\u060c \u0631\u0648\u0634\u06cc \u0628\u0631\u0627\u06cc \u067e\u06cc\u0634 \u06af\u0648\u06cc\u06cc \u0648\u0627\u06a9\u0646\u0634 \u0628\u06cc\u0645\u0627\u0631"},"content":{"rendered":"<p style=\"text-align: center;\"><strong>Human microdosing for the prediction of patient response<br \/>\n<\/strong>\u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af \u0627\u0646\u0633\u0627\u0646\u06cc\u060c \u0631\u0648\u0634\u06cc \u0628\u0631\u0627\u06cc \u067e\u06cc\u0634 \u06af\u0648\u06cc\u06cc \u0648\u0627\u06a9\u0646\u0634 \u0628\u06cc\u0645\u0627\u0631<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-2104\" src=\"http:\/\/noanimaltesting.ir\/wp-content\/uploads\/2020\/03\/ncbi.png\" alt=\"\" width=\"96\" height=\"33\" \/><\/p>\n<p style=\"text-align: center;\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3113695\/<\/p>\n<p style=\"text-align: right;\">\u00a0\u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af \u0631\u0648\u0634\u06cc \u0627\u0633\u062a \u06a9\u0647 \u0627\u062c\u0627\u0632\u0647 \u0645\u06cc\u200c\u062f\u0647\u062f \u062a\u0627 \u0631\u0641\u062a\u0627\u0631 \u062f\u0627\u0631\u0648\u0647\u0627 \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u062f\u0648\u0632\u0647\u0627\u06cc \u0628\u0633\u06cc\u0627\u0631 \u067e\u0627\u06cc\u06cc\u0646 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\u0645\u0642\u0627\u0644\u0627\u062a \u062f\u06cc\u06af\u0631 \u0645\u0648\u0631\u062f \u0628\u0631\u0631\u0633\u06cc \u0642\u0631\u0627\u0631 \u06af\u0631\u0641\u062a\u0647 \u0627\u0633\u062a [\u06f1\u060c\u06f2]\u061b \u0627\u06af\u0631\u0686\u0647 \u0628\u06cc\u0634\u062a\u0631 \u062a\u0644\u0627\u0634 \u0647\u0627 \u062a\u0627 \u0627\u0645\u0631\u0648\u0632 \u0628\u0631 \u0631\u0648\u06cc \u067e\u06cc\u0634 \u0628\u06cc\u0646\u06cc\u200c\u0647\u0627\u06cc \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u06a9\u06cc\u0646\u062a\u06cc\u06a9 (PK) \u062c\u0647\u062a \u062a\u0633\u0631\u06cc\u0639 \u062f\u0631 \u0633\u0627\u062e\u062a \u062f\u0627\u0631\u0648 \u0645\u062a\u0645\u0631\u06a9\u0632 \u0634\u062f\u0647 \u0627\u0633\u062a\u060c \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af \u0627\u0632 \u062f\u0644 \u062a\u062d\u0642\u06cc\u0642\u0627\u062a \u0633\u0645 \u0634\u0646\u0627\u0633\u06cc \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0645\u062a\u0648\u0644\u062f \u0634\u062f\u0647 \u0627\u0633\u062a [\u06f3 \u06f1\u06f0] \u0648 \u0627\u06a9\u0646\u0648\u0646 \u0648 \u0627\u06a9\u0646\u0648\u0646 \u0628\u0647 \u06a9\u0627\u0631\u0628\u0631\u062f \u0647\u0627\u06cc \u062a\u0634\u062e\u06cc\u0635 \u067e\u0632\u0634\u06a9\u06cc \u06af\u0633\u062a\u0631\u0634 \u06cc\u0627\u0641\u062a\u0647 \u0627\u0633\u062a.<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-medium wp-image-2092 aligncenter\" src=\"http:\/\/noanimaltesting.ir\/wp-content\/uploads\/2020\/03\/mp-300x131.png\" alt=\"\" width=\"300\" height=\"131\" srcset=\"https:\/\/noanimaltesting.ir\/wp-content\/uploads\/2020\/03\/mp-200x87.png 200w, https:\/\/noanimaltesting.ir\/wp-content\/uploads\/2020\/03\/mp-300x131.png 300w, https:\/\/noanimaltesting.ir\/wp-content\/uploads\/2020\/03\/mp.png 339w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p style=\"text-align: right;\">\u062f\u0631 \u0627\u06cc\u0646\u062c\u0627\u060c \u0645\u0627 \u06cc\u06a9 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\u0627\u06cc\u0646 \u0641\u0631\u0636 \u06a9\u0647 \u062f\u0627\u062f\u0647 \u0647\u0627 \u0628\u0627 \u062f\u0648\u0632\u0647\u0627\u06cc \u0628\u0627\u0644\u0627\u062a\u0631 \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u0644\u0648\u0698\u06cc\u06a9\u060c \u067e\u06cc\u0634 \u0628\u06cc\u0646\u06cc \u06a9\u0646\u0646\u062f\u0647 \u0633\u06cc\u0646\u062a\u06cc\u06a9 \u062f\u0627\u0631\u0648\u06cc\u06cc \u062e\u0648\u0627\u0647\u0646\u062f \u0628\u0648\u062f.<\/p>\n<p style=\"text-align: right;\">\u067e\u06cc\u0634 \u0628\u06cc\u0646\u06cc \u0645\u06cc \u0634\u0648\u062f \u062f\u0631 \u0622\u06cc\u0646\u062f\u0647 \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u0633\u0645 \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u0647\u0627 \u0628\u0647 \u0648\u06cc\u0698\u0647 \u0628\u0627 \u062a\u0648\u062c\u0647 \u0628\u0647 \u062f\u0633\u062a\u0648\u0631 \u0627\u0644\u0639\u0645\u0644 \u0627\u062e\u06cc\u0631 FDA \u0627\u06cc\u0627\u0644\u0627\u062a \u0645\u062a\u062d\u062f\u0647 \u0648 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loading=\"lazy\" class=\"alignnone size-medium wp-image-2106 aligncenter\" src=\"http:\/\/noanimaltesting.ir\/wp-content\/uploads\/2020\/03\/fda1-300x167.jpg\" alt=\"\" width=\"300\" height=\"167\" srcset=\"https:\/\/noanimaltesting.ir\/wp-content\/uploads\/2020\/03\/fda1-200x112.jpg 200w, https:\/\/noanimaltesting.ir\/wp-content\/uploads\/2020\/03\/fda1-300x168.jpg 300w, https:\/\/noanimaltesting.ir\/wp-content\/uploads\/2020\/03\/fda1.jpg 301w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\">\u00a0\u0627\u06af\u0631\u0686\u0647 \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 PET \u0628\u0631\u0627\u06cc \u062a\u0635\u0648\u06cc\u0631\u0628\u0631\u062f\u0627\u0631\u06cc \u0648 \u06a9\u0631\u0648\u0645\u0627\u062a\u0648\u06af\u0631\u0627\u0641\u06cc \u0645\u0627\u06cc\u0639 \u0647\u0645\u0631\u0627\u0647 \u0628\u0627 \u0637\u06cc\u0641 \u0633\u0646\u062c\u06cc \u062c\u0631\u0645\u06cc \u0628\u0631\u0627\u06cc \u0627\u0646\u062f\u0627\u0632\u0647 \u06af\u06cc\u0631\u06cc \u0628\u0631\u062e\u06cc \u062a\u0631\u06a9\u06cc\u0628\u0627\u062a \u0627\u0646\u062c\u0627\u0645 \u0634\u062f\u0647 \u0627\u0633\u062a\u060c \u0627\u0645\u0627 \u0627\u06a9\u062b\u0631 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0627\u0632 \u0637\u06cc\u0641 \u0633\u0646\u062c\u06cc \u062c\u0631\u0645\u06cc \u0634\u062a\u0627\u0628 \u062f\u0647\u0646\u062f\u0647 \u0641\u0648\u0642 \u0627\u0644\u0639\u0627\u062f\u0647 \u062d\u0633\u0627\u0633 (AMS) \u0628\u0631\u0627\u06cc \u062a\u0634\u062e\u06cc\u0635 \u062a\u0631\u06a9\u06cc\u0628\u0627\u062a \u0646\u0634\u0627\u0646 \u06af\u0630\u0627\u0631\u06cc \u0634\u062f\u0647 \u0628\u0627 \u06f1\u06f4C \u00a0\u062f\u0631 \u0646\u0645\u0648\u0646\u0647 \u0647\u0627\u06cc \u0628\u06cc\u0648\u0644\u0648\u0698\u06cc\u06a9\u06cc \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0645\u06cc \u06a9\u0646\u0646\u062f. 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right;\">\u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af \u0628\u0647 \u062a\u0627\u0632\u06af\u06cc \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u0627\u0633\u062a\u0631\u0627\u062a\u0698\u06cc \u0628\u0631\u0627\u06cc \u062a\u0634\u062e\u06cc\u0635 \u067e\u0632\u0634\u06a9\u06cc \u0645\u0637\u0631\u062d \u0634\u062f\u0647 \u0627\u0633\u062a [\u06f1\u06f3\u060c \u06f1\u06f7_\u06f1\u06f9].<br \/>\n\u0645\u0632\u0627\u06cc\u0627\u06cc \u0686\u0646\u06cc\u0646 \u0631\u0648\u06cc\u06a9\u0631\u062f\u06cc \u0639\u0628\u0627\u0631\u062a\u0646\u062f \u0627\u0632:<\/p>\n<ul style=\"text-align: right;\">\n<li>\u0622\u0646\u0627\u0644\u06cc\u0632 \u062f\u0631\u0648\u0646 \u062a\u0646\u06cc \u062f\u0648\u0631 \u0631\u06cc\u0632\u0634 \u062f\u0627\u0631\u0648 \u00a0(drug disposition)\u0628\u0631\u0627\u06cc \u0628\u0647 \u062f\u0633\u062a \u0622\u0648\u0631\u062f\u0646 \u0627\u0637\u0644\u0627\u0639\u0627\u062a \u0641\u0646\u0648\u062a\u06cc\u067e\u06cc \u062f\u0631 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\u0641\u062f\u0631\u0627\u0644 \u0641\u0646 \u0622\u0648\u0631\u06cc \u0633\u0648\u0626\u06cc\u0633 \u06cc\u06a9 \u0627\u0628\u0632\u0627\u0631 AMS \u00a0\u062c\u0645\u0639 \u0648 \u062c\u0648\u0631 \u0631\u0627 \u062a\u0648\u0644\u06cc\u062f \u06a9\u0631\u062f\u0646\u062f \u06a9\u0647 \u0628\u0647 \u0637\u0648\u0631 \u062e\u0627\u0635 \u0628\u0631\u0627\u06cc \u0639\u0644\u0648\u0645 \u062f\u0627\u0631\u0648\u06cc\u06cc \u0637\u0631\u0627\u062d\u06cc \u0634\u062f\u0647 \u0627\u0633\u062a.<\/p>\n<p style=\"text-align: right;\">[\u06f1\u06f0\u06f2].<\/p>\n<p style=\"text-align: right;\">\u0647\u06cc\u0686 \u062f\u0644\u06cc\u0644\u06cc \u0646\u0638\u0631\u06cc \u0648\u062c\u0648\u062f \u0646\u062f\u0627\u0631\u062f \u06a9\u0647 \u0627\u0645\u06a9\u0627\u0646 \u0628\u0647 \u06a9\u0627\u0631 \u06af\u0631\u0641\u062a\u0646 \u0646\u0645\u0648\u0646\u0647 \u0628\u0647 \u0634\u06a9\u0644 \u062e\u0648\u062f\u06a9\u0627\u0631 \u062f\u0631 AMS \u00a0\u0648\u062c\u0648\u062f \u0646\u062f\u0627\u0634\u062a\u0647 \u0628\u0627\u0634\u062f. Skipper \u0648 \u0647\u0645\u06a9\u0627\u0631\u0627\u0646 \u062f\u0631 \u0627\u0646\u0633\u062a\u06cc\u062a\u0648\u06cc \u0641\u0646\u0627\u0648\u0631\u06cc \u0645\u0627\u0633\u0627\u0686\u0648\u0633\u062a \u0633\u06cc\u0633\u062a\u0645 \u062a\u0648\u0644\u06cc\u062f \u0627\u062d\u062a\u0631\u0627\u0642 \u0628\u0647 \u06a9\u0645\u06a9 \u0644\u06cc\u0632\u0631 \u0631\u0627 \u0628\u0631\u0627\u06cc \u062a\u0648\u0644\u06cc\u062f \u00a0\u06f1\u06f4 CO2 \u00a0\u0627\u062e\u062a\u0631\u0627\u0639 \u06a9\u0631\u062f\u0646\u062f \u06a9\u0647 \u0647\u0645 \u0627\u06a9\u0646\u0648\u0646 \u0628\u0647 \u0634\u06a9\u0644 \u062a\u062c\u0627\u0631\u06cc \u062f\u0631 \u062f\u0633\u062a\u0631\u0633 \u0627\u0633\u062a [\u06f2\u06f0_ \u06f2\u06f2]. \u00a0\u06f1\u06f4 CO2 \u062d\u0627\u0635\u0644\u0647 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0627\u0632 \u0637\u0631\u06cc\u0642 \u06cc\u06a9 \u0645\u0646\u0628\u0639 \u06cc\u0648\u0646\u06cc\u0632\u0647 \u06a9\u0646\u0646\u062f\u0647 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\u0627\u06cc\u0646 \u06a9\u0627\u0631 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0628\u0627 \u0627\u0646\u0628\u0627\u0634\u062a \u0627\u0631\u0632\u0634 \u06af\u0630\u0627\u0631\u06cc \u0646\u0633\u0628\u06cc \u062e\u062f\u0645\u0627\u062a (CPT) \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f\u060c \u06a9\u062f \u0647\u0627\u06cc\u06cc \u06a9\u0647 \u0628\u0647 \u0647\u0631 \u0648\u0638\u06cc\u0641\u0647 \u0648 \u062e\u062f\u0645\u0627\u062a\u06cc \u06a9\u0647 \u06cc\u06a9 \u067e\u0632\u0634\u06a9 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0628\u0631\u0627\u06cc \u0628\u0627\u0632\u067e\u0631\u062f\u0627\u062e\u062a \u06cc\u0627 \u062a\u0647\u06cc\u0647 \u06a9\u062f\u0647\u0627\u06cc CPT \u00a0\u062e\u0627\u0635 \u0647\u0631 \u0622\u0632\u0645\u0648\u0646 \u0628\u0647 \u0628\u06cc\u0645\u0627\u0631 \u0627\u0631\u0627\u0626\u0647 \u062f\u0647\u062f. \u0628\u0627 \u062a\u0648\u062c\u0647 \u0628\u0647 \u062a\u0648\u0627\u0646 \u0639\u0645\u0644\u06cc\u0627\u062a\u06cc\u060c \u06cc\u06a9 \u062a\u06a9\u0646\u0633\u06cc\u0646 \u0622\u0632\u0645\u0627\u06cc\u0634\u06af\u0627\u0647 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u062d\u062f\u0627\u06a9\u062b\u0631 \u06f3\u06f0\u06f0 \u0646\u0645\u0648\u0646\u0647 \u062f\u0631 \u0631\u0648\u0632 \u0627\u0646\u062c\u0627\u0645 \u062f\u0647\u062f. \u0628\u0631\u062e\u06cc \u0627\u0632 \u062f\u0633\u062a\u06af\u0627\u0647 \u0647\u0627\u06cc AMS \u0645\u06cc \u062a\u0648\u0627\u0646\u0646\u062f \u0628\u06cc\u0634 \u0627\u0632 \u06f2\u06f0\u060c\u06f0\u06f0\u06f0-\u06f4\u06f0\u060c\u06f0\u06f0\u06f0 \u0646\u0645\u0648\u0646\u0647 \u062f\u0631 \u0633\u0627\u0644 \u0627\u0646\u062c\u0627\u0645 \u062f\u0647\u0646\u062f \u06a9\u0647 \u06a9\u0627\u0631\u0622\u06cc\u06cc \u0645\u0646\u0637\u0642\u06cc \u0627\u06cc \u0628\u0631\u0627\u06cc \u06a9\u0627\u0631\u0628\u0631\u062f\u0647\u0627\u06cc \u062a\u0634\u062e\u06cc\u0635 \u0628\u0627\u0644\u06cc\u0646\u06cc \u0627\u0633\u062a. \u06af\u0631\u0648\u0647 \u0645\u0627 \u0639\u0644\u0627\u0642\u0647 \u0645\u0646\u062f \u0628\u0647 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 AMS \u0628\u0631\u0627\u06cc \u067e\u06cc\u0634 \u0628\u06cc\u0646\u06cc \u0627\u06cc\u0646 \u0645\u0648\u0636\u0648\u0639 \u0627\u0633\u062a \u06a9\u0647 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u0633\u0631\u0637\u0627\u0646 \u0628\u0647 \u0634\u06cc\u0645\u06cc \u062f\u0631\u0645\u0627\u0646\u06cc \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 \u067e\u0644\u0627\u062a\u06cc\u0646 \u067e\u0627\u0633\u062e \u062e\u0648\u0627\u0647\u0646\u062f \u062f\u0627\u062f \u06cc\u0627 \u0646\u0647. \u0627\u0632 \u0627\u06cc\u0646 \u0631\u0648\u0634 \u062f\u0631 \u0633\u0627\u0644 \u06f2\u06f0\u06f0\u06f8 \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 \u062f\u0631 \u062d\u062f\u0648\u062f \u06f3\u06f0\u06f0\u06f0\u06f0\u06f0 \u0628\u06cc\u0645\u0627\u0631 \u062f\u0631 \u0627\u06cc\u0627\u0644\u0627\u062a \u0645\u062a\u062d\u062f\u0647 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0634\u062f.<\/p>\n<p style=\"text-align: right;\">\u0627\u0646\u062c\u0627\u0645 \u0622\u0632\u0645\u0648\u0646 \u0647\u0627\u06cc \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af \u0631\u0648\u06cc \u0647\u0632\u0627\u0631\u0627\u0646 \u0628\u06cc\u0645\u0627\u0631\u060c \u0633\u0637\u062d \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647 \u0648 \u062f\u0631 \u0639\u06cc\u0646 \u062d\u0627\u0644 \u0648\u0627\u0642\u0639 \u0628\u06cc\u0646\u0627\u0646\u0647 \u0627\u06cc \u0627\u0632 \u0627\u0641\u0632\u0627\u06cc\u0634 \u062a\u0648\u0627\u0646 \u0639\u0645\u0644\u06cc\u0627\u062a\u06cc \u0631\u0627 \u062f\u0631 \u0645\u0642\u0627\u06cc\u0633\u0647 \u0628\u0627 \u0631\u0648\u0634 \u0647\u0627\u06cc \u0641\u0639\u0644\u06cc \u0646\u0634\u0627\u0646 \u0645\u06cc \u062f\u0647\u062f. \u0627\u0632 \u062f\u06cc\u062f\u06af\u0627\u0647 \u062a\u062c\u0627\u0631\u06cc\u060c \u0627\u0646\u06af\u06cc\u0632\u0647 \u0642\u0627\u0646\u0639 \u06a9\u0646\u0646\u062f\u0647\u060c \u067e\u062a\u0627\u0646\u0633\u06cc\u0644 \u062a\u0623\u06cc\u06cc\u062f \u062f\u0627\u0631\u0648\u06cc \u0646\u0634\u0627\u0646\u062f\u0627\u0631 \u0627\u06cc\u0632\u0648\u062a\u0648\u067e \u0627\u0632 \u0633\u0648\u06cc NDA \u0627\u0633\u062a \u06a9\u0647 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f \u0627\u0646\u062d\u0635\u0627\u0631\u06cc \u0628\u0648\u062f\u0646 \u0628\u0627\u0632\u0627\u0631 \u0631\u0627 \u0628\u0631\u0627\u06cc \u0641\u0631\u0648\u0634\u0646\u062f\u0647 \u062a\u06a9\u0646\u0648\u0644\u0648\u0698\u06cc AMS \u0641\u0631\u0627\u0647\u0645 \u06a9\u0646\u062f\u060c \u00a0\u062d\u062a\u06cc \u0627\u06af\u0631 \u0622\u0646\u0627\u0644\u0648\u06af \u0646\u0634\u0627\u0646 \u06af\u0630\u0627\u0631\u06cc \u0646\u0634\u062f\u0647 \u0642\u0628\u0644\u0627\u064b \u062a\u0648\u0633\u0637 FDA \u062a\u0623\u06cc\u06cc\u062f \u0634\u062f\u0647 \u0628\u0627\u0634\u062f.<\/p>\n<p style=\"text-align: right;\">\u0627\u062e\u06cc\u0631\u0627\u064b \u0627\u0632 \u062a\u0644\u0627\u0634 \u0647\u0627\u06cc \u062a\u062d\u0642\u06cc\u0642\u0627\u062a\u06cc UC \u00a0\u062f\u06cc\u0648\u06cc\u0633 \u0648 \u0622\u0632\u0645\u0627\u06cc\u0634\u06af\u0627\u0647 \u0645\u0644\u06cc \u0644\u0627\u0631\u0646\u0633 \u0644\u06cc\u0648\u0631\u0645\u0648\u0631 (LLNL) \u0686\u0646\u062f\u06cc\u0646 \u06a9\u0627\u0631\u0628\u0631\u062f \u0628\u0627\u0644\u06cc\u0646\u06cc \u0627\u0645\u06cc\u062f\u0648\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 AMS \u062f\u0631 \u062a\u0634\u062e\u06cc\u0635 \u062d\u0627\u0635\u0644 \u0634\u062f\u0647 \u0627\u0633\u062a [\u06f1\u06f0\u06f3].<br \/>\nVitalea Biosciences \u00a0[\u06f1\u06f0\u06f2]\u060c \u06cc\u06a9 \u0634\u0631\u06a9\u062a \u0645\u0633\u062a\u0642\u0644 \u062c\u062f\u06cc\u062f \u0627\u0632 UC \u00a0\u062f\u06cc\u0648\u06cc\u0633 \u06a9\u0647 \u0645\u062c\u0648\u0632 \u0641\u0646\u0627\u0648\u0631\u06cc LLNL AMS \u0631\u0627 \u06af\u0631\u0641\u062a\u0647\u060c \u062f\u0631 \u062d\u0627\u0644 \u062a\u0647\u06cc\u0647 \u0622\u0632\u0645\u0648\u0646\u06cc \u0628\u0631\u0627\u06cc \u0627\u0646\u062f\u0627\u0632\u0647 \u06af\u06cc\u0631\u06cc \u062c\u0630\u0628 \u0648\u06cc\u062a\u0627\u0645\u06cc\u0646 B12 \u062f\u0631 \u0627\u0646\u0633\u0627\u0646 \u0627\u0633\u062a [\u06f1\u06f7].<\/p>\n<p style=\"text-align: right;\">\u0641\u0631\u0627\u0647\u0645\u06cc \u0632\u06cc\u0633\u062a\u06cc \u0648\u06cc\u062a\u0627\u0645\u06cc\u0646 B12 \u0628\u0631\u0627\u06cc \u0633\u0644\u0627\u0645\u062a\u06cc \u0645\u0647\u0645 \u0627\u0633\u062a. \u062c\u0630\u0628 \u0648\u06cc\u062a\u0627\u0645\u06cc\u0646 \u00a0B12 \u062f\u0631 \u06a9\u0645 \u062e\u0648\u0646\u06cc \u0628\u062f\u062e\u06cc\u0645\u060c \u06cc\u06a9 \u0628\u06cc\u0645\u0627\u0631\u06cc \u062e\u0648\u062f \u0627\u06cc\u0645\u0646\u06cc \u0627\u0633\u062a \u06a9\u0647 \u0633\u0644\u0648\u0644 \u0647\u0627\u06cc \u067e\u0627\u0631\u06cc\u062a\u0627\u0644 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\u0645\u0642\u0627\u0648\u0645\u062a \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0634\u06cc\u0645\u06cc\u0627\u06cc\u06cc \u0647\u0633\u062a\u06cc\u0645 \u06a9\u0647 \u0628\u0631 \u0627\u0633\u0627\u0633 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u067e\u06cc\u0634 \u0628\u0627\u0644\u06cc\u0646\u06cc \u0645\u0627 \u0628\u0627 \u06a9\u0627\u0631\u0628\u0648\u067e\u0644\u0627\u062a\u06cc\u0646 \u0648 \u0627\u06af\u0632\u0627\u0644\u06cc \u067e\u0644\u0627\u062a\u06cc\u0646 [\u06f1\u06f8\u060c\u06f1\u06f9] \u0648 \u0646\u06cc\u0632 \u062f\u0627\u062f\u0647 \u0647\u0627\u06cc \u0628\u0627\u0644\u06cc\u0646\u06cc \u06af\u0633\u062a\u0631\u062f\u0647 \u0627\u06cc \u0627\u0632 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u062a\u062d\u062a \u062f\u0631\u0645\u0627\u0646 \u0628\u0627 \u062f\u0648\u0632\u0647\u0627\u06cc \u062f\u0631\u0645\u0627\u0646\u06cc \u0634\u06cc\u0645\u06cc \u062f\u0631\u0645\u0627\u0646\u06cc \u0634\u06a9\u0644 \u06af\u0631\u0641\u062a\u0647 \u0627\u0633\u062a.<\/p>\n<p style=\"text-align: right;\">\u062f\u0627\u062f\u0647 \u0647\u0627\u06cc \u062d\u0627\u0635\u0644 \u0627\u0632 \u0622\u0633\u06cc\u0628 \u0628\u0647 DNA \u0627\u0632 \u0646\u0645\u0648\u0646\u0647 \u0647\u0627\u06cc \u062e\u0648\u0646 \u0648 \u0628\u06cc\u0648\u067e\u0633\u06cc \u062a\u0648\u0645\u0648\u0631 \u0627\u0632 \u06f1\u06f0\u06f0 \u0628\u06cc\u0645\u0627\u0631 \u0628\u0627 \u0646\u062a\u0627\u06cc\u062c \u0628\u0627\u0644\u06cc\u0646\u06cc\u060c \u0645\u0627\u0646\u0646\u062f \u0628\u0642\u0627 \u0628\u062f\u0648\u0646 \u067e\u06cc\u0634\u0631\u0641\u062a \u0628\u06cc\u0645\u0627\u0631\u06cc\u060c \u0628\u0642\u0627\u06cc \u06a9\u0644\u06cc \u0648 \u0639\u0648\u0627\u0631\u0636 \u062c\u0627\u0646\u0628\u06cc \u067e\u0633 \u0627\u0632 \u0634\u0631\u0648\u0639 \u0634\u06cc\u0645\u06cc \u062f\u0631\u0645\u0627\u0646\u06cc \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 \u067e\u0644\u0627\u062a\u06cc\u0646\u060c \u0645\u0642\u0627\u06cc\u0633\u0647 \u062e\u0648\u0627\u0647\u062f \u0634\u062f. \u0639\u0644\u0627\u0648\u0647 \u0628\u0631 \u0627\u06cc\u0646\u060c \u062a\u0639\u062f\u0627\u062f \u0627\u0646\u06af\u0634\u062a \u0634\u0645\u0627\u0631\u06cc \u0627\u0632 \u0646\u0634\u0627\u0646\u06af\u0631\u0647\u0627\u06cc \u0628\u06cc\u0627\u0646 \u0698\u0646 \u06a9\u0647 \u0628\u0647 \u062f\u0642\u062a \u0627\u0646\u062a\u062e\u0627\u0628 \u0634\u062f\u0647 \u0627\u0646\u062f\u060c \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0631\u0648\u0634Real-time PCR \u00a0\u0627\u0646\u062f\u0627\u0632\u0647 \u06af\u06cc\u0631\u06cc \u0645\u06cc \u0634\u0648\u0646\u062f \u062a\u0627 \u0698\u0646\u0648\u062a\u06cc\u067e \u0628\u0627 \u0641\u0646\u0648\u062a\u06cc\u067e \u0628\u0631\u0627\u06cc \u0647\u0631 \u0628\u06cc\u0645\u0627\u0631 \u0645\u0642\u0627\u06cc\u0633\u0647 \u0634\u0648\u062f. \u0645\u0627 \u0627\u0646\u062a\u0638\u0627\u0631 \u062f\u0627\u0631\u06cc\u0645 \u06a9\u0647 \u0634\u06a9\u0644 \u06af\u06cc\u0631\u06cc \u0648 \u062a\u0631\u0645\u06cc\u0645 \u0622\u0633\u06cc\u0628 DNA \u0646\u0627\u0634\u06cc \u0627\u0632 \u00a0\u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632 \u0628\u0631 \u067e\u0627\u06cc\u0647 \u067e\u0644\u0627\u062a\u06cc\u0646 \u0628\u0627\u0634\u062f<\/p>\n<p style=\"text-align: right;\">\u0645\u0627 \u0627\u0646\u062a\u0638\u0627\u0631 \u062f\u0627\u0631\u06cc\u0645 \u06a9\u0647 \u0634\u06a9\u0644 \u06af\u06cc\u0631\u06cc \u0648 \u062a\u0631\u0645\u06cc\u0645 \u0622\u0633\u06cc\u0628 DNA \u0646\u0627\u0634\u06cc \u0627\u0632 \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632 \u0628\u0631 \u067e\u0627\u06cc\u0647 \u067e\u0644\u0627\u062a\u06cc\u0646\u060c \u0622\u0633\u06cc\u0628 \u0647\u0627\u06cc \u0646\u0627\u0634\u06cc \u0627\u0632 \u062f\u0648\u0632 \u062f\u0631\u0645\u0627\u0646\u06cc \u0631\u0627 \u06a9\u0647 \u0642\u0628\u0644\u0627\u064b \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0634\u0627\u062e\u0635 \u0645\u0647\u0645 \u0646\u062a\u06cc\u062c\u0647 \u062a\u0639\u06cc\u06cc\u0646 \u0634\u062f\u0647 \u0627\u0633\u062a\u060c \u067e\u06cc\u0634\u06af\u0648\u06cc\u06cc \u06a9\u0646\u062f [\u06f2\u06f3].<\/p>\n<p style=\"text-align: right;\">\u062f\u0631 \u062d\u0627\u0644\u06cc \u06a9\u0647 \u0647\u0646\u0648\u0632 \u0645\u0634\u062e\u0635 \u0646\u06cc\u0633\u062a \u06a9\u0647 \u0622\u06cc\u0627 \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af \u06cc\u06a9 \u0627\u0633\u062a\u0631\u0627\u062a\u0698\u06cc \u0632\u06cc\u0633\u062a\u06cc \u0628\u0647 \u0648\u0627\u0642\u0639 \u0645\u0646\u0627\u0633\u0628 \u0628\u0631\u0627\u06cc \u062a\u0634\u062e\u06cc\u0635 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0627\u0633\u062a\u060c \u0627\u06cc\u0646 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0627\u06cc\u0646 \u0627\u0645\u06a9\u0627\u0646 \u0631\u0627 \u062f\u0627\u0631\u062f \u06a9\u0647 \u0628\u062a\u0648\u0627\u0646\u062f \u067e\u0632\u0634\u06a9\u06cc \u0634\u062e\u0635\u06cc \u00a0\u0631\u0627 \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 \u0627\u0646\u0648\u0627\u0639 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0647\u0627 \u0627\u0645\u06a9\u0627\u0646 \u067e\u0630\u06cc\u0631 \u06a9\u0646\u062f \u0648 \u0628\u0646\u0627\u0628\u0631\u0627\u06cc\u0646 \u062a\u062d\u0642\u06cc\u0642\u0627\u062a \u0648 \u062a\u0648\u0633\u0639\u0647 \u0647\u0627\u06cc \u0628\u06cc\u0634\u062a\u0631 \u062f\u0631 \u0627\u06cc\u0646 \u0632\u0645\u06cc\u0646\u0647 \u0631\u0627 \u062a\u0648\u062c\u06cc\u0647 \u0645\u06cc \u06a9\u0646\u062f.<\/p>\n<p style=\"text-align: right;\">Bibliography<\/p>\n<ol style=\"text-align: right;\">\n<li>Brown K, Dingley KH, Turteltaub KW. Accelerator mass spectrometry for biomedical research.<\/li>\n<\/ol>\n<p style=\"text-align: right;\">Methods Enzymol. 2005; 402:423\u2013\u06f4\u06f4\u06f3\u066b [PubMed: 16401518]<\/p>\n<ol style=\"text-align: right;\" start=\"2\">\n<li>Lappin G, Stevens L. Biomedical accelerator mass spectrometry: recent applications in metabolism<\/li>\n<\/ol>\n<p style=\"text-align: right;\">and pharmacokinetics. Expert Opin Drug Metab Toxicol. 2008; 4(8):1021\u2013\u06f1\u06f0\u06f3\u06f3\u066b [PubMed:<\/p>\n<p style=\"text-align: right;\">\u06f1\u06f8\u06f6\u06f8\u06f0\u06f4\u06f3\u06f8]<\/p>\n<ol style=\"text-align: right;\" start=\"3\">\n<li>Hah SS, Mundt JM, Kim HM, Sumbad RA, Turteltaub KW, Henderson PT. Measurement of 7,8-<\/li>\n<\/ol>\n<p style=\"text-align: right;\">dihydro-8-oxo-2\u2032-deoxyguanosine metabolism in MCF-7 cells at low concentrations using<\/p>\n<p style=\"text-align: right;\">accelerator mass spectrometry. Proc Natl Acad Sci USA. 2007; 104(27):11203\u2013\u06f1\u06f1\u06f2\u06f0\u06f8\u066b [PubMed:<\/p>\n<p style=\"text-align: right;\">\u06f1\u06f7\u06f5\u06f9\u06f2\u06f1\u06f1\u06f8]<\/p>\n<ol style=\"text-align: right;\" start=\"4\">\n<li>Zhou X, Liberman RG, Skipper PL, Margolin Y, Tannenbaum SR, Dedon PC. Quantification of<\/li>\n<\/ol>\n<p style=\"text-align: right;\">DNA strand breaks and abasic sites by oxime derivatization and accelerator mass spectrometry:<\/p>\n<p style=\"text-align: right;\">application to gamma-radiation and peroxynitrite. Anal Biochem. 2005; 343(1):84\u2013\u06f9\u06f2\u066b [PubMed:<\/p>\n<p style=\"text-align: right;\">\u06f1\u06f5\u06f9\u06f6\u06f4\u06f5\u06f4\u06f2]<\/p>\n<ol style=\"text-align: right;\" start=\"5\">\n<li>Choi MH, Skipper PL, Wishnok JS, Tannenbaum SR. Characterization of testosterone 11\u03b2-<\/li>\n<\/ol>\n<p style=\"text-align: right;\">hydroxylation catalyzed by human liver microsomal cytochromes P450. Drug Metab Dispos. 2005;<\/p>\n<p style=\"text-align: right;\">\u06f3\u06f3(\u06f6):\u06f7\u06f1\u06f4\u2013\u06f7\u06f1\u06f8\u066b [PubMed: 15764715]<\/p>\n<ol style=\"text-align: right;\" start=\"6\">\n<li>Hillier SM, Marquis JC, Zayas B, et al. DNA adducts formed by a novel antitumor agent 11\u03b2-<\/li>\n<\/ol>\n<p style=\"text-align: right;\">dichloro in vitro and in vivo. Mol Cancer Ther. 2006; 5(4):977\u2013\u06f9\u06f8\u06f4\u066b [PubMed: 16648569]<\/p>\n<ol style=\"text-align: right;\" start=\"7\">\n<li>Watanabe K, Liberman RG, Skipper PL, Tannenbaum SR, Guengerich FP. Analysis of DNA<\/li>\n<\/ol>\n<p style=\"text-align: right;\">adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane,<\/p>\n<p style=\"text-align: right;\">dibromomethane, and dichloromethane using HPLC\/accelerator mass spectrometry and relevance to<\/p>\n<p style=\"text-align: right;\">risk estimates. Chem Res Toxicol. 2007; 20(11):1594\u2013\u06f1\u06f6\u06f0\u06f0\u066b [PubMed: 17907789]<\/p>\n<ol style=\"text-align: right;\" start=\"8\">\n<li>Tompkins EM, Farmer PB, Lamb JH, et al. A novel 14C-postlabeling assay using accelerator mass<\/li>\n<\/ol>\n<p style=\"text-align: right;\">spectrometry for the detection of O6-methyldeoxy-guanosine adducts. Rapid Commun Mass<\/p>\n<p style=\"text-align: right;\">Spectrom. 2006; 20(5):883\u2013\u06f8\u06f9\u06f1\u066b [PubMed: 16470516]<\/p>\n<ol style=\"text-align: right;\" start=\"9\">\n<li>Marsden DA, Jones DJ, Britton RG, et al. Dose-response relationships for N7-(2-<\/li>\n<\/ol>\n<p style=\"text-align: right;\">hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide: evidence for a novel mechanism<\/p>\n<p style=\"text-align: right;\">of endogenous adduct formation. Cancer Res. 2009; 69(7):3052\u2013\u06f3\u06f0\u06f5\u06f9\u066b [PubMed: 19276345]<\/p>\n<ol style=\"text-align: right;\" start=\"10\">\n<li>Jubert C, Mata J, Bench G, et al. Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B1<\/li>\n<\/ol>\n<p style=\"text-align: right;\">pharmacokinetics in human volunteers. Cancer Prev Res. 2009; 2(12):1015\u2013\u06f1\u06f0\u06f2\u06f2\u066b<\/p>\n<ol style=\"text-align: right;\" start=\"11\">\n<li>Dingley KH, Roberts ML, Velsko CA, Turteltaub KW. Attomole detection of 3H in biological<\/li>\n<\/ol>\n<p style=\"text-align: right;\">samples using accelerator mass spectrometry: application in low-dose, dual-isotope tracer studies<\/p>\n<p style=\"text-align: right;\">Henderson and Pan Page 4<\/p>\n<p style=\"text-align: right;\">Bioanalysis. Author manuscript; available in PMC 2011 June 13.<\/p>\n<p style=\"text-align: right;\">NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript<\/p>\n<p style=\"text-align: right;\">in conjunction with 14C accelerator mass spectrometry. Chem Res Toxicol. 1998; 11(10):1217\u2013<\/p>\n<ol style=\"text-align: right;\" start=\"1222\">\n<li>[PubMed: 9778319]<\/li>\n<li>Fitzgerald RL, Hillegonds DJ, Burton DW, et al. 41Ca and accelerator mass spectrometry to<\/li>\n<\/ol>\n<p style=\"text-align: right;\">monitor calcium metabolism in end stage renal disease patients. Clin Chem. 2005; 51(11):2095\u2013<\/p>\n<ol style=\"text-align: right;\" start=\"2102\">\n<li>[PubMed: 16141289]<\/li>\n<li>Denk E, Hillegonds D, Hurrell RF, et al. Evaluation of 41calcium as a new approach to assess<\/li>\n<\/ol>\n<p style=\"text-align: right;\">changes in bone metabolism: effect of a bisphosphonate intervention in postmenopausal women<\/p>\n<p style=\"text-align: right;\">with low bone mass. J Bone Miner Res. 2007; 22(10):1518\u2013\u06f1\u06f5\u06f2\u06f5\u066b [PubMed: 17576167]<\/p>\n<ol style=\"text-align: right;\" start=\"14\">\n<li>Lappin G, Stevens L. Biomedical accelerator mass spectrometry: recent applications in metabolism<\/li>\n<\/ol>\n<p style=\"text-align: right;\">and pharmacokinetics. Expert Opin Drug Metab Toxicol. 2008; 4(8):1021\u2013\u06f1\u06f0\u06f3\u06f3\u066b [PubMed:<\/p>\n<p style=\"text-align: right;\">\u06f1\u06f8\u06f6\u06f8\u06f0\u06f4\u06f3\u06f8]<\/p>\n<ol style=\"text-align: right;\" start=\"15\">\n<li>Ings RM. Microdosing: a valuable tool for accelerating drug development and the role of<\/li>\n<\/ol>\n<p style=\"text-align: right;\">bioanalytical methods in meeting the challenge. Bioanalysis. 2009; 1(7):1293\u2013\u06f1\u06f3\u06f0\u06f5\u066b [PubMed:<\/p>\n<p style=\"text-align: right;\">\u06f2\u06f1\u06f0\u06f8\u06f3\u06f0\u06f5\u06f2]<\/p>\n<ol style=\"text-align: right;\" start=\"16\">\n<li>Sandhu P, Vogel JS, Rose MJ, et al. Evaluation of microdosing strategies for studies in preclinical<\/li>\n<\/ol>\n<p style=\"text-align: right;\">drug development: demonstration of linear pharmacokinetics in dogs of a nucleoside analog over a<\/p>\n<p style=\"text-align: right;\">\u06f5\u06f0-fold dose range. Drug Metab Dispos. 2004; 32(11):1254\u2013\u06f1\u06f2\u06f5\u06f9\u066b [PubMed: 15286054]<\/p>\n<ol style=\"text-align: right;\" start=\"17\">\n<li>Carkeet C, Dueker SR, Lango J, et al. Human vitamin B12 absorption measurement by accelerator<\/li>\n<\/ol>\n<p style=\"text-align: right;\">mass spectrometry using specifically labeled (14) C-cobalamin. Proc Natl Acad Sci USA. 2006;<\/p>\n<p style=\"text-align: right;\">\u06f1\u06f0\u06f3(\u06f1\u06f5):\u06f5\u06f6\u06f9\u06f4\u2013\u06f5\u06f6\u06f9\u06f9\u066b [PubMed: 16585531]<\/p>\n<ol style=\"text-align: right;\" start=\"18\">\n<li>Hah SS, Stivers KM, de Vere White R, Henderson PT. Kinetics of carboplatin\u2013DNA binding in<\/li>\n<\/ol>\n<p style=\"text-align: right;\">genomic DNA and bladder cancer cells as determined by accelerator mass spectrometry. Chem<\/p>\n<p style=\"text-align: right;\">Res Toxicol. 2006; 19(5):622\u2013\u06f6\u06f2\u06f6\u066b [PubMed: 16696564]<\/p>\n<ol style=\"text-align: right;\" start=\"19\">\n<li>Hah SS, Sumbad RA, de Vere White R, Turteltaub KW, Henderson PT. Characterization of<\/li>\n<\/ol>\n<p style=\"text-align: right;\">oxaliplatin-DNA adduct formation in DNA and differentiation of cancer cell drug sensitivity at<\/p>\n<p style=\"text-align: right;\">microdose concentrations. Chem Res Toxicol. 2007; 20(12):1745\u2013\u06f1\u06f7\u06f5\u06f1\u066b [PubMed: 18001055]<\/p>\n<ol style=\"text-align: right;\" start=\"20\">\n<li>Liberman RG, Tannenbaum SR, Hughey BJ, et al. An interface for direct analysis of 14C in<\/li>\n<\/ol>\n<p style=\"text-align: right;\">nonvolatile samples by accelerator mass spectrometry. Anal Chem. 2004; 76(2):328\u2013\u06f3\u06f3\u06f4\u066b<\/p>\n<p style=\"text-align: right;\">[PubMed: 14719879]<\/p>\n<ol style=\"text-align: right;\" start=\"21\">\n<li>Prakash C, Shaffer CL, Tremaine LM, et al. Application of liquid chromatography\u2013accelerator<\/li>\n<\/ol>\n<p style=\"text-align: right;\">mass spectrometry (LC\u2013AMS) to evaluate the metabolic profiles of a drug candidate in human<\/p>\n<p style=\"text-align: right;\">urine and plasma. Drug Metab Lett. 2007; 1(3):226\u2013\u06f2\u06f3\u06f1\u066b [PubMed: 19356047]<\/p>\n<ol style=\"text-align: right;\" start=\"22\">\n<li>Flarakos J, Liberman RG, Tannenbaum SR, Skipper PL. Integration of continuous-flow accelerator<\/li>\n<\/ol>\n<p style=\"text-align: right;\">mass spectrometry with chromatography and mass-selective detection. Anal Chem. 2008; 80(13):<\/p>\n<p style=\"text-align: right;\">\u06f5\u06f0\u06f7\u06f9\u2013\u06f5\u06f0\u06f8\u06f5\u066b [PubMed: 18494504]<\/p>\n<ol style=\"text-align: right;\" start=\"23\">\n<li>Simon GR, Begum M, Bepler G. Setting the stage for tailored chemotherapy in the management of<\/li>\n<\/ol>\n<p style=\"text-align: right;\">non-small cell lung cancer. Future Oncol. 2008; 4(1):51\u2013\u06f5\u06f9\u066b [PubMed: 18241000]<\/p>\n<p style=\"text-align: right;\">Websites<\/p>\n<ol style=\"text-align: right;\" start=\"101\">\n<li>European Union Microdose AMS Partnership Programme. www.eumapp.com<\/li>\n<li>Vitalea Biosciences Incorporated. www.vitaleascience.com<\/li>\n<li>Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory.<\/li>\n<\/ol>\n<p style=\"text-align: right;\">https:\/\/cams.llnl.gov<\/p>\n<p style=\"text-align: right;\">Henderson and Pan Page 5<\/p>\n<p style=\"text-align: right;\">Bioanalysis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Human microdosing for the prediction of patient response \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af \u0627\u0646\u0633\u0627\u0646\u06cc\u060c \u0631\u0648\u0634\u06cc \u0628\u0631\u0627\u06cc \u067e\u06cc\u0634 \u06af\u0648\u06cc\u06cc \u0648\u0627\u06a9\u0646\u0634 \u0628\u06cc\u0645\u0627\u0631 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3113695\/ \u00a0\u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af \u0631\u0648\u0634\u06cc \u0627\u0633\u062a \u06a9\u0647 \u0627\u062c\u0627\u0632\u0647 \u0645\u06cc\u200c\u062f\u0647\u062f \u062a\u0627 \u0631\u0641\u062a\u0627\u0631 \u062f\u0627\u0631\u0648\u0647\u0627 \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u062f\u0648\u0632\u0647\u0627\u06cc [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2094,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[45,7,2,30],"tags":[],"_links":{"self":[{"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/posts\/2091"}],"collection":[{"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2091"}],"version-history":[{"count":9,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/posts\/2091\/revisions"}],"predecessor-version":[{"id":2107,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/posts\/2091\/revisions\/2107"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/media\/2094"}],"wp:attachment":[{"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}