{"id":242,"date":"2012-06-11T14:43:32","date_gmt":"2012-06-11T14:43:32","guid":{"rendered":"http:\/\/noanimaltesting.ir\/?p=242"},"modified":"2017-09-15T07:36:20","modified_gmt":"2017-09-15T07:36:20","slug":"%d8%b1%d9%88%d8%b4-%d9%85%db%8c%da%a9%d8%b1%d9%88%d8%af%d9%88%d8%b2%db%8c%d9%86%da%af-%d8%ac%d8%a7%db%8c%da%af%d8%b2%db%8c%d9%86-%d8%a2%d8%b2%d9%85%d8%a7%db%8c%d8%b4-%d8%b1%d9%88%db%8c-%d8%ad%db%8c","status":"publish","type":"post","link":"https:\/\/noanimaltesting.ir\/?p=242","title":{"rendered":"\u0631\u0648\u0634 \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af : \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u0622\u0632\u0645\u0627\u06cc\u0634 \u0631\u0648\u06cc \u062d\u06cc\u0648\u0627\u0646\u0627\u062a \u062f\u0631 \u062a\u062d\u0642\u06cc\u0642\u0627\u062a \u067e\u0632\u0634\u06a9\u06cc"},"content":{"rendered":"

\u062a\u062d\u0642\u06cc\u0642 \u0648 \u062a\u0631\u062c\u0645\u0647 : \u062d\u0627\u0645\u062f \u0635\u0648\u0641\u06cc<\/span><\/span><\/strong><\/p>\n

\u067e\u06cc\u0686\u06cc\u062f\u06af\u06cc \u0647\u0627\u06cc \u0631\u0648\u0632 \u0627\u0641\u0632\u0648\u0646 \u0645\u0631\u0628\u0648\u0637 \u0628\u0647 \u062e\u0635\u0648\u0635\u06cc\u0627\u062a \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u06a9\u06cc\u0646\u062a\u06cc\u06a9\u060c \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u062f\u06cc\u0646\u0627\u0645\u06cc\u06a9 \u0648 \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u0698\u0646\u0648\u0645\u06cc\u06a9 \u062f\u0627\u0631\u0648\u0647\u0627 \u0648 \u0631\u0648\u0646\u062f \u0647\u0632\u06cc\u0646\u0647 \u00ad\u0628\u0631 \u0648 \u0627\u0633\u062a\u0647\u0644\u0627\u06a9\u06cc \u062a\u062d\u0642\u06cc\u0642\u0627\u062a \u067e\u0632\u0634\u06a9\u06cc\u060c \u0631\u0648\u0646\u062f \u0641\u0639\u0644\u06cc \u0627\u06a9\u062a\u0634\u0627\u0641\u0627\u062a \u062f\u0627\u0631\u0648\u06cc\u06cc \u0631\u0627 \u0628\u0627 \u0627\u0646\u062a\u0642\u0627\u062f\u0627\u062a \u0628\u0633\u06cc\u0627\u0631\u06cc \u0645\u0648\u0627\u062c\u0647 \u0633\u0627\u062e\u062a\u0647 \u0627\u0633\u062a <\/span>(\u06f1<\/a>)<\/span><\/span>. <\/span>\u0628\u0631 \u0637\u0628\u0642 \u0628\u0631\u0631\u0633\u06cc \u0647\u0627\u06cc \u0628\u0647 \u0639\u0645\u0644 \u0622\u0645\u062f\u0647\u060c \u0632\u0645\u0627\u0646 \u0644\u0627\u0632\u0645 \u0628\u0631\u0627\u06cc \u0648\u0631\u0648\u062f \u06cc\u06a9 \u062f\u0627\u0631\u0648 \u0628\u0647 \u0628\u0627\u0632\u0627\u0631 \u062f\u0627\u0631\u0648\u06cc\u06cc\u060c \u062a\u0627 \u06f1\u06f5<\/span> \u0633\u0627\u0644 \u0648 \u0647\u0632\u06cc\u0646\u0647 \u0647\u0627\u06cc \u0645\u0631\u0628\u0648\u0637 \u0628\u0647 \u0622\u0646\u060c \u062a\u0627 \u06cc\u06a9 \u0645\u06cc\u0644\u06cc\u0627\u0631\u062f \u062f\u0644\u0627\u0631 \u062a\u062e\u0645\u06cc\u0646 \u0632\u062f\u0647 \u0645\u06cc \u0634\u0648\u062f<\/span><\/span> (\u06f2<\/a>)<\/span><\/span>.<\/span> \u0627\u06cc\u0646 \u0645\u0633\u0626\u0644\u0647 \u0633\u0627\u0632\u0645\u0627\u0646 \u062e\u0648\u0631\u0627\u06a9 \u0648 \u062f\u0627\u0631\u0648\u06cc \u0622\u0645\u0631\u06cc\u06a9\u0627<\/em> (<\/span><\/span>FDA<\/span><\/span>) <\/span>\u0631\u0627 \u0628\u0631 \u0622\u0646 \u062f\u0627\u0634\u062a \u062a\u0627 \u0628\u0627 \u0627\u0646\u062a\u0634\u0627\u0631 \u0628\u06cc\u0627\u0646\u06cc\u0647 \u0627\u06cc \u062f\u0631 \u0633\u0627\u0644 \u06f2\u06f0\u06f0\u06f4<\/span> \u0628\u0627 \u0639\u0646\u0648\u0627\u0646 \u00ab \u06af\u0630\u0631\u06af\u0627\u0647 \u0628\u062d\u0631\u0627\u0646\u06cc \u00bb\u060c \u0646\u0648\u0627\u0642\u0635 \u0645\u0648\u062c\u0648\u062f \u062f\u0631 \u0631\u0648\u0646\u062f \u0641\u0639\u0644\u06cc \u0627\u06a9\u062a\u0634\u0627\u0641 \u062f\u0627\u0631\u0648 \u0648 \u0646\u06cc\u0627\u0632 \u0628\u0647 \u0631\u0648\u0634 \u0647\u0627\u06cc \u0646\u0648\u06cc\u0646 \u062f\u0631 \u062a\u062d\u0642\u06cc\u0642\u0627\u062a \u062f\u0627\u0631\u0648\u06cc\u06cc \u0631\u0627 \u0627\u0628\u0631\u0627\u0632 \u062f\u0627\u0631\u062f <\/span>(<\/span><\/span><\/span><\/p>\n

\u0631\u0648\u0646\u062f \u0641\u0639\u0644\u06cc \u0627\u06a9\u062a\u0634\u0627\u0641 \u062f\u0627\u0631\u0648\u060c \u0647\u0645\u0627\u0646\u06af\u0648\u0646\u0647 \u062f\u0631 \u0634\u06a9\u0644 \u06f1<\/span> \u0646\u06cc\u0632 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a\u060c \u0627\u0632 \u06cc\u06a9 \u0645\u0631\u062d\u0644\u0647\u00ad \u06cc \u067e\u06cc\u0634\u0627\u0628\u0627\u0644\u06cc\u0646\u06cc \u0648 \u0686\u0647\u0627\u0631 \u0645\u0631\u062d\u0644\u0647 \u00ad\u06cc \u0628\u0627\u0644\u06cc\u0646\u06cc (<\/span>\u0645\u0648\u0633\u0648\u0645 \u0628\u0647 \u0641\u0627\u0632\u0647\u0627\u06cc \u06f1<\/span> \u062a\u0627 \u06f4) <\/span>\u062a\u0634\u06a9\u06cc\u0644 \u0645\u06cc \u0634\u0648\u062f. \u062f\u0631 \u0627\u06cc\u0646 \u0628\u06cc\u0646\u060c \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u062d\u06cc\u0648\u0627\u0646\u06cc\u060c \u0633\u0647\u0645 \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647\u06cc \u0627\u0632 \u0645\u0631\u0627\u062d\u0644 \u0627\u06a9\u062a\u0634\u0627\u0641\u06cc \u062f\u0627\u0631\u0648 \u0631\u0627 \u0628\u0647 \u062e\u0648\u062f \u0627\u062e\u062a\u0635\u0627\u0635 \u062f\u0627\u062f\u0647 \u0627\u0633\u062a <\/span>(\u06f4<\/a>)<\/span><\/span>.<\/span><\/span><\/span><\/p>\n

\"1\"<\/a><\/p>\n

\u0631\u0648\u0634 \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af<\/em> (<\/span><\/span>microdosing<\/span><\/span>)<\/span> \u0645\u0648\u0633\u0648\u0645 \u0628\u0647 \u0641\u0627\u0632 \u0635\u0641\u0631<\/em>\u060c \u06a9\u0647 \u0628\u0647 \u0645\u0646\u0638\u0648\u0631 \u062a\u0633\u0631\u06cc\u0639 \u062f\u0631 \u0631\u0648\u0646\u062f \u0627\u06a9\u062a\u0634\u0627\u0641\u06cc \u062f\u0627\u0631\u0648\u060c \u0637\u0631\u0627\u062d\u06cc \u0634\u062f\u0647 \u0627\u0633\u062a\u060c \u0627\u0632 \u062d\u062c\u0645 \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647\u06cc \u0627\u0632 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u062d\u06cc\u0648\u0627\u0646\u06cc \u06a9\u0627\u0633\u062a\u0647 \u0648 \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u067e\u06cc\u0634\u0646\u0647\u0627\u062f\u06cc \u0645\u0646\u0627\u0633\u0628\u06cc \u0628\u0631\u0627\u06cc \u062a\u062d\u0642\u06cc\u0642\u0627\u062a \u062d\u06cc\u0648\u0627\u0646\u06cc \u062f\u0631 \u0645\u0631\u0627\u062d\u0644 \u0627\u0628\u062a\u062f\u0627\u06cc\u06cc \u0627\u06a9\u062a\u0634\u0627\u0641 \u062f\u0627\u0631\u0648 \u062e\u0648\u0627\u0647\u062f \u0628\u0648\u062f <\/span>(\u06f4<\/a>)<\/span><\/span>. \u0634\u06a9\u0644 \u06f2<\/span>\u060c \u062a\u0648\u0636\u06cc\u062d\u0627\u062a \u0645\u0632\u0628\u0648\u0631 \u0631\u0627 \u0628\u0647 \u0635\u0648\u0631\u062a \u0634\u0645\u0627\u062a\u06cc\u06a9 \u0628\u06cc\u0627\u0646 \u0645\u06cc \u062f\u0627\u0631\u062f.<\/span><\/span><\/p>\n

\"2-microdosing\"<\/a><\/p>\n

\u0633\u0627\u0628\u0642\u0647 \u00ad\u06cc \u0645\u0637\u0627\u0644\u0639\u0627\u062a\u06cc \u0648 \u0639\u0645\u0644\u06cc\u0627\u062a\u06cc \u0631\u0648\u0634 \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af\u060c \u0628\u0647 \u062f\u0647\u0647\u00ad \u06cc \u0627\u062e\u06cc\u0631 \u0628\u0627\u0632 \u0645\u06cc \u06af\u0631\u062f\u062f <\/span>(\u06f5<\/a>)<\/span><\/span>.<\/span> \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u060c \u0639\u0646\u0648\u0627\u0646\u06cc \u0627\u0633\u062a \u06a9\u0647 \u0628\u0647 \u0645\u0642\u0627\u062f\u06cc\u0631 \u0628\u0633\u06cc\u0627\u0631 \u067e\u0627\u0626\u06cc\u0646 \u0627\u0632 \u0645\u0648\u0627\u062f \u0645\u0624\u062b\u0631\u0647\u00ad \u06cc \u062f\u0627\u0631\u0648\u06cc\u06cc \u0627\u0637\u0644\u0627\u0642 \u0645\u06cc \u06af\u0631\u062f\u062f <\/span>(\u06f6<\/a>)<\/span><\/span>.<\/span> \u0627\u06cc\u0646 \u0645\u0642\u062f\u0627\u0631\u060c \u0628\u0647 \u0637\u0648\u0631 \u062a\u0642\u0631\u06cc\u0628\u06cc \u0628\u0631\u0627\u0628\u0631 \u0628\u0627 \u06cc\u06a9 \u0635\u062f\u0645 \u062f\u0648\u0632\u0647\u0627\u06cc \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u0644\u0648\u0698\u06cc\u06a9 \u062f\u0627\u0631\u0648\u06cc\u06cc \u0628\u0648\u062f\u0647 \u0648 \u0628\u0646\u0627\u0628\u0631\u0627\u06cc\u0646 \u0628\u0627 \u0628\u0647 \u06a9\u0627\u0631 \u06af\u06cc\u0631\u06cc \u0645\u0642\u0627\u062f\u06cc\u0631 \u0627\u0646\u062f\u06a9 \u062f\u0627\u0631\u0648\u0647\u0627\u060c \u0627\u062d\u062a\u0645\u0627\u0644 \u0628\u0631\u0648\u0632 \u0639\u0648\u0627\u0631\u0636 \u062c\u0627\u0646\u0628\u06cc \u0648 \u0633\u0645\u06cc\u062a \u062d\u0627\u0635\u0644 \u0627\u0632 \u062a\u0632\u0631\u06cc\u0642 \u0645\u0648\u0627\u062f \u0627\u0646\u062a\u062e\u0627\u0628\u06cc \u0628\u0647 \u062f\u0627\u0648\u0637\u0644\u0628\u06cc\u0646 \u0627\u0646\u0633\u0627\u0646\u06cc \u0628\u0647 \u0645\u06cc\u0632\u0627\u0646 \u0632\u06cc\u0627\u062f\u06cc \u067e\u0627\u0626\u06cc\u0646 \u0645\u06cc \u0622\u06cc\u062f. \u062f\u0631 \u0648\u0627\u0642\u0639 \u0628\u0627 \u06a9\u0645\u06a9 \u0627\u06cc\u0646 \u0631\u0648\u0634\u060c \u0628\u0627 \u062d\u0641\u0638 \u0627\u062b\u0631\u0627\u062a \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u06a9\u06cc\u0646\u062a\u06cc\u06a9 \u062f\u0627\u0631\u0648\u0647\u0627\u060c \u0633\u062f \u0646\u0627\u0634\u06cc \u0627\u0632 \u0628\u0631\u0648\u0632 \u0627\u062b\u0631\u0627\u062a \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u0644\u0648\u0698\u06cc\u06a9 \u0648 \u062a\u0648\u06a9\u0633\u06cc\u06a9\u0648\u0644\u0648\u0698\u06cc\u06a9 \u06a9\u0647 \u0639\u0627\u0645\u0644 \u0645\u062d\u062f\u0648\u062f \u06a9\u0646\u0646\u062f\u0647 \u0628\u0633\u06cc\u0627\u0631\u06cc \u0627\u0632 \u067e\u0698\u0648\u0647\u0634 \u0647\u0627\u06cc \u0627\u0646\u0633\u0627\u0646\u06cc \u0645\u06cc \u0628\u0627\u0634\u062f\u060c \u0628\u0631\u0686\u06cc\u062f\u0647 \u062e\u0648\u0627\u0647\u062f \u0634\u062f <\/span>(\u06f5<\/a>)<\/span><\/span>.
\n<\/span><\/span><\/span><\/span><\/p>\n

\u0627\u0633\u0627\u0633 \u0627\u06cc\u0646 \u0631\u0648\u0634\u060c<\/span><\/span> \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 \u0627\u06cc\u0646 \u0648\u0627\u0642\u0639\u06cc\u062a \u0645\u06cc \u0628\u0627\u0634\u062f \u06a9\u0647 \u0628\u0633\u06cc\u0627\u0631\u06cc \u0627\u0632 \u0631\u0648\u0646\u062f\u0647\u0627\u06cc \u06a9\u0646\u062a\u0631\u0644 \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u06a9\u06cc\u0646\u062a\u06cc\u06a9\u060c \u063a\u06cc\u0631 \u0648\u0627\u0628\u0633\u062a\u0647 \u0628\u0647 \u0633\u0637\u0648\u062d \u062e\u0648\u0646\u06cc \u062f\u0627\u0631\u0648\u0647\u0627 \u0628\u0648\u062f\u0647 \u0648 \u0627\u0632 \u0627\u06cc\u0646 \u0631\u0648 \u062f\u0631 \u067e\u0698\u0648\u0647\u0634 \u0647\u0627\u06cc \u0628\u0631\u0631\u0633\u06cc \u062e\u0635\u0648\u0635\u06cc\u0627\u062a \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u06a9\u06cc\u0646\u062a\u06cc\u06a9 \u062f\u0627\u0631\u0648\u0647\u0627\u060c \u0627\u0645\u06a9\u0627\u0646 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0645\u0642\u0627\u062f\u06cc\u0631 \u0628\u0633\u06cc\u0627\u0631 \u067e\u0627\u0626\u06cc\u0646 \u062f\u0627\u0631\u0648\u0647\u0627 \u0645\u06cc\u0633\u0631 \u0645\u06cc \u0634\u0648\u062f. \u067e\u06cc\u0634\u0631\u0641\u062a \u0647\u0627\u06cc \u062a\u06a9\u0646\u0648\u0644\u0648\u0698\u06cc\u06a9 \u062f\u0631 \u062e\u0635\u0648\u0635 \u0631\u062f\u06cc\u0627\u0628\u06cc \u062f\u0642\u06cc\u0642 \u062a\u0631 \u0645\u0648\u0627\u062f \u0634\u06cc\u0645\u06cc\u0627\u06cc\u06cc \u0648 \u0638\u0647\u0648\u0631 \u062f\u0633\u062a\u06af\u0627\u0647 \u0627\u0633\u067e\u06a9\u062a\u0631\u0648\u0645\u062a\u0631 \u0634\u062a\u0627\u0628 \u062f\u0647\u0646\u062f\u0647 \u06cc \u062c\u0631\u0645\u06cc (AMS)<\/span>\u060c \u0642\u062f\u0631\u062a \u0639\u0645\u0644\u06a9\u0631\u062f \u0627\u06cc\u0646 \u0631\u0648\u0634 \u0631\u0627 \u0628\u0647 \u0645\u06cc\u0632\u0627\u0646 \u0632\u06cc\u0627\u062f\u06cc \u0628\u0647\u0628\u0648\u062f \u0628\u062e\u0634\u06cc\u062f\u0647 \u0627\u0633\u062a <\/span>(\u06f4<\/a>)<\/span>.<\/span><\/span><\/span><\/p>\n

<\/div>\n

FDA \u0644\u0627\u0632\u0645 \u0628\u0647 \u0630\u06a9\u0631 \u0627\u0633\u062a \u06a9\u0647<\/span><\/span><\/span> \u062f\u0631 \u062a\u0648\u0633\u0639\u0647\u00ad \u06cc \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af\u060c \u062a\u0639\u06cc\u06cc\u0646 \u0633\u0642\u0641 \u0645\u0642\u0627\u062f\u06cc\u0631 \u06a9\u0627\u0631\u0628\u0631\u062f\u06cc \u062f\u0631 \u0627\u06cc\u0646 \u0631\u0648\u0634 \u0631\u0627 \u0646\u06cc\u0632 \u062f\u0631 \u062f\u0633\u062a\u0648\u0631 \u06a9\u0627\u0631 \u062e\u0648\u062f \u0642\u0631\u0627\u0631 \u062f\u0627\u062f\u0647 \u0627\u0633\u062a <\/span>(\u06f7<\/a>)<\/span><\/span>.<\/span> \u0627\u0632 \u0627\u06cc\u0646 \u0631\u0648\u060c \u06cc\u06a9 \u06a9\u0627\u0631\u0628\u0631\u062f \u062f\u06cc\u06af\u0631 \u0645\u06cc\u06a9\u0631\u0648\u062f\u0648\u0632\u06cc\u0646\u06af\u060c \u062f\u0631 \u062a\u0639\u06cc\u06cc\u0646 \u062d\u062f\u0627\u0642\u0644 \u0645\u0642\u0627\u062f\u06cc\u0631 \u067e\u06cc\u0634\u0646\u0647\u0627\u062f\u06cc \u062c\u0647\u062a \u0627\u0646\u062c\u0627\u0645 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0641\u0627\u0632 \u0646\u062e\u0633\u062a \u062e\u0648\u0627\u0647\u062f \u0628\u0648\u062f. \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0627\u06cc\u0646 \u0631\u0648\u0634\u060c \u0647\u0632\u06cc\u0646\u0647 \u0647\u0627\u06cc \u0645\u0631\u0628\u0648\u0637 \u0628\u0647 \u0627\u0646\u062c\u0627\u0645 \u0641\u0627\u0632 \u0646\u062e\u0633\u062a \u0627\u06a9\u062a\u0634\u0627\u0641 \u062f\u0627\u0631\u0648 \u062a\u0627 \u062f\u0647 \u062f\u0631\u0635\u062f \u06a9\u0627\u0647\u0634 \u062e\u0648\u0627\u0647\u062f \u06cc\u0627\u0641\u062a. \u0633\u0631\u0639\u062a \u0646\u062a\u06cc\u062c\u0647\u00ad \u062f\u0647\u06cc \u0628\u0627\u0644\u0627\u060c \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0645\u0642\u0627\u062f\u06cc\u0631 \u067e\u0627\u0626\u06cc\u0646 \u062f\u0627\u0631\u0648\u0647\u0627 \u0648 \u062d\u0630\u0641 \u062d\u062c\u0645 \u06a9\u062b\u06cc\u0631\u06cc \u0627\u0632 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u062d\u06cc\u0648\u0627\u0646\u06cc \u0627\u0632 \u062f\u06cc\u06af\u0631 \u0645\u0632\u0627\u06cc\u0627\u06cc \u0628\u0627\u0631\u0632 \u0627\u06cc\u0646 \u0631\u0648\u0634 \u062a\u062d\u0642\u06cc\u0642\u0627\u062a\u06cc \u0645\u06cc \u0628\u0627\u0634\u062f <\/span>(\u06f1<\/a>)<\/span>.<\/span><\/span><\/span><\/p>\n

<\/div>\n

\u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0628\u0647 \u0639\u0645\u0644 \u0622\u0645\u062f\u0647\u060c \u06a9\u0627\u0631\u0627\u06cc\u06cc \u0627\u06cc\u0646 \u0631\u0648\u0634 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u0645\u0646\u0627\u0633\u0628 \u062f\u0631 \u0645\u0631\u0627\u062d\u0644 \u0627\u0648\u0644\u06cc\u0647 \u0627\u06a9\u062a\u0634\u0627\u0641 \u062f\u0627\u0631\u0648\u06cc\u06cc \u0631\u0627 \u062a\u0623\u0626\u06cc\u062f \u0646\u0645\u0648\u062f\u0647 \u0627\u0646\u062f <\/span>(\u06f8<\/a>)<\/span><\/span>.<\/span> \u0647\u0645 \u0627\u06a9\u0646\u0648\u0646 \u0646\u06cc\u0632 \u0627\u06cc\u0646 \u0631\u0648\u0634 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u0645\u062a\u062f \u062a\u062d\u0642\u06cc\u0642\u0627\u062a\u06cc \u062f\u0631 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0628\u0627\u0644\u06cc\u0646\u06cc \u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0642\u0631\u0627\u0631 \u0645\u06cc \u06af\u06cc\u0631\u062f <\/span>(\u06f9<\/a>, \u06f1\u06f0<\/a>)<\/span>.<\/span><\/span><\/span><\/p>\n

\u00a0<\/span><\/p>\n

references<\/strong><\/span><\/p>\n

<\/div>\n

<\/a>\u06f1<\/span><\/strong><\/span><\/p>\n

Rani PU, Naidu MU. Phase 0 – Microdosing strategy in clinical trials. Indian J Pharmacol. 2008 Nov;40(6):240-2.<\/span><\/span><\/p>\n

<\/div>\n

<\/a>\u06f2<\/span><\/strong><\/span><\/p>\n

DiMasi JA, Hansen RW, Grabowski HG. The price of innovation: new estimates of drug development costs. J Health Econ. 2003 Mar;22(2):151-85.<\/span><\/span><\/p>\n

<\/div>\n

<\/a>\u06f3<\/span><\/strong><\/span><\/p>\n

U.S. Department of Health and Human Services FaDA. Innovation or Stagnation:\u00a0 Challenge and Opportunity on the Critical Path to New Medical Products.\u00a0 \u06f2\u06f0\u06f0\u06f4; Available from:<\/span>www.fda.gov\/ScienceResearch\/SpecialTopics\/CriticalPathInitiative\/CriticalPathOpportunitiesReports\/ucm077262.htm<\/a>.<\/span><\/span><\/p>\n

<\/div>\n

<\/a>\u06f4<\/span><\/strong><\/span><\/p>\n

Rowland M, Professor E, Manchester Uo. Microdosing and the 3Rs. National Centre for the Replacement, Refinement and Reduction of Animals in Research; 2006; Available from:http:\/\/www.nc3rs.org.uk\/downloaddoc.<\/span>asp?id=339&page=193&skin=0<\/a>.<\/span><\/span><\/p>\n

<\/div>\n

<\/a>\u06f5<\/span><\/strong><\/span><\/p>\n

Tewari T, Mukherjee S. Microdosing: concept, application and relevance. Perspect Clin Res. 2010 Apr;1(2):61-3.<\/span><\/span><\/p>\n

<\/div>\n

<\/a>\u06f6<\/strong><\/span><\/span><\/p>\n

<\/a>\u00a0<\/span>Garner RC, Lappin G. The phase 0 microdosing concept. Br J Clin Pharmacol. 2006 Apr;61(4):367-70.<\/span><\/span><\/p>\n

<\/div>\n

<\/a>\u06f7<\/span><\/strong><\/span><\/p>\n

<\/a>Bertino JS, Jr., Greenberg HE, Reed MD. American College of Clinical Pharmacology position statement on the use of microdosing in the drug development process. J Clin Pharmacol. 2007 Apr;47(4):418-22.<\/span><\/span><\/p>\n

<\/div>\n

<\/a>\u06f8<\/span><\/strong><\/span><\/p>\n

<\/a>\u00a0 <\/span>Lappin G, Kuhnz W, Jochemsen R, Kneer J, Chaudhary A, Oosterhuis B, et al. Use of microdosing to predict pharmacokinetics at the therapeutic dose: experience with 5 drugs. Clin Pharmacol Ther. 2006 Sep;80(3):203-15.<\/span><\/span><\/p>\n

<\/div>\n

<\/a>\u06f9<\/span><\/strong><\/span><\/p>\n

<\/a>Croft M, Keely B, Morris I, Tann L, Lappin G. Predicting drug candidate victims of drug-drug interactions, using microdosing. Clin Pharmacokinet. 2012 Apr 1;51(4):237-46.<\/span><\/span><\/p>\n

<\/div>\n

<\/a>\u06f1\u06f0<\/strong><\/span><\/span><\/p>\n

<\/a>Calvert AH, Plummer R. The development of phase I cancer trial methodologies: the use of pharmacokinetic and pharmacodynamic end points sets the scene for phase 0 cancer clinical trials. Clin Cancer Res. 2008 Jun 15;14(12):3664-9.<\/span><\/span><\/p>\n

<\/div>\n

\u00a0<\/span><\/p>\n

\n

\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u062a\u062d\u0642\u06cc\u0642 \u0648 \u062a\u0631\u062c\u0645\u0647 : \u062d\u0627\u0645\u062f \u0635\u0648\u0641\u06cc \u067e\u06cc\u0686\u06cc\u062f\u06af\u06cc \u0647\u0627\u06cc \u0631\u0648\u0632 \u0627\u0641\u0632\u0648\u0646 \u0645\u0631\u0628\u0648\u0637 \u0628\u0647 \u062e\u0635\u0648\u0635\u06cc\u0627\u062a \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u06a9\u06cc\u0646\u062a\u06cc\u06a9\u060c \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u062f\u06cc\u0646\u0627\u0645\u06cc\u06a9 \u0648 \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u0698\u0646\u0648\u0645\u06cc\u06a9 \u062f\u0627\u0631\u0648\u0647\u0627 \u0648 \u0631\u0648\u0646\u062f \u0647\u0632\u06cc\u0646\u0647 \u00ad\u0628\u0631 \u0648 \u0627\u0633\u062a\u0647\u0644\u0627\u06a9\u06cc \u062a\u062d\u0642\u06cc\u0642\u0627\u062a \u067e\u0632\u0634\u06a9\u06cc\u060c \u0631\u0648\u0646\u062f \u0641\u0639\u0644\u06cc \u0627\u06a9\u062a\u0634\u0627\u0641\u0627\u062a \u062f\u0627\u0631\u0648\u06cc\u06cc […]<\/p>\n","protected":false},"author":1,"featured_media":247,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[8,21,30],"tags":[],"_links":{"self":[{"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/posts\/242"}],"collection":[{"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=242"}],"version-history":[{"count":2,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/posts\/242\/revisions"}],"predecessor-version":[{"id":1511,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/posts\/242\/revisions\/1511"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=\/wp\/v2\/media\/247"}],"wp:attachment":[{"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/noanimaltesting.ir\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}